The 2023 American Society of Clinical Oncology (ASCO) Annual Meeting brings together oncologists from around the world to share the latest cutting-edge research under the theme Partnering With Patients: The Cornerstone of Cancer Care and Research. Taking place June 2-6, the Annual Meeting will feature 20 first- and senior-authored abstracts from Innovation Faculty, Fellows, and staff at the Penn Center for Cancer Care Innovation (PC3I). 

The work of PC3I researchers is anchored to patient engagement, equitable and engaged cancer care, and meaningful relationships between patients and clinicians. This year, these strategies include:

• leveraging digital technologies to reduce time-receiving care
• utilizing guaranteed income to reduce financial toxicity
• testing equitable ways to bridge gaps in clinician-patient communications.

Throughout, PC3I Faculty and Fellows highlight thoughtful and patient-centered implementations to innovate cancer care delivery. 

Real-world outcomes of first-line immune checkpoint inhibitors with or without chemotherapy in KRAS G12C altered NSCLC according to PD-L1 status.

Charu Aggarwal, Lamisa Parkar, Iker Huerga, Kate Sasser, Halla Nimeiri, Beata Korytowsky, Jyoti Patel.
Poster Session: June 4th, 9:00 ET – Abstract: 9136 | Poster: 124 

CAN-2409 plus prodrug with standard of care immune checkpoint inhibitor for patients with stage III/IV NSCLC.

Charu Aggarwal, Daniel Sterman, Fabien Maldonado, Christine Bestvina, Janani Reisenauer, Howard Li, Sonam Puri, Omar Ibrahim, Randy Swan, Audra Caine, Lenika Lopez, Andrea Manzanera, Francesca Barone, Christopher Matheny, William Nichols, Paul Peter Tak.
Poster Session: June 4th, 9:00 ET – Abstract TPS9162 | Poster: 138b 

EGRET: A first-in-human study of the novel antibody-drug conjugate (ADC) AZD9592 as monotherapy or combined with other anticancer agents in patients (pts) with advanced solid tumors.

Charu Aggarwal, Christopher Azzoli, Alexander Spira, Benjamin Solomon, Xiuning Le, Christian Rolfo, David Planchard, Enriqueta Felip, Yi-Long Wu, Myung-Ju Ahn, Tanguy Seiwert, Koichi Goto, Analía Azaro, Delphine Lissa, Oday Hamid, Lara McGrath, Rhiannon Maudsley, Fernanda Arnaldez, Italia Grenga, Erminia Massarelli.
Poster Session: June 3rd, 9:00 ET – Abstract: TPS2156 | Poster: 352b 

Are we ready to mitigate time toxicity of cancer care? Oncologists’ perceptions on digital interventions to fast-track cancer care.

Erin Bange, Kerry Coughlin, Timothy Brown, Andrea Bilger, Eesha Balar, Dhivya Arasappan, Michelle Nnaji, Elise Chong, Pamela Cappucci, Daniel Ragusano, Lindsey Zinck, Adam Fredo, Caitlin O’Neill, Wenrui Li, Mira Mamtani, Carmen Guerra, Ronac Mamtani.
Poster Session: June 5th, 2:15 ET – Abstract: 1537 | Poster: 131 

Phase 3 study of durvalumab combined with oleclumab or monalizumab in patients with unresectable stage III NSCLC (PACIFIC-9).

Fabrice Barlesi, Sarah Goldberg, Helen Mann, Aarthi Gopinathan, Michael Newton, Charu Aggarwal.
Poster Session: June 4th, 9:00 ET – Abstract: TPS8610 | Poster: 231b 

Clinical pathways innovation: A lesson on the value of clinician based feedback and collaboration with Flatiron Health.

Christopher D’avella, Erin Bange, Aditi Singh, David Dougherty, Peter Gabriel, Rebecca Maniago, Jennifer Miao, Colin Harvey, Marcello Ricottone, Lawrence Shulman.
Poster Session: June 5th, 2:15 ET – Abstract: 1578 | Poster: 172 

Cost of care associated with utilization of telehealth in clinical trials.

Emily Gleason, Elizabeth Tubridy, Leslie Andriani, Destiny Uwawuike, Simon Gunter, Nathanael Koelper, Heidi Harvie, Emily Ko.
Publication Only – Abstract: e13682 

External validation of biomechanical computed tomography for fracture risk classification in metastatic hormone sensitive prostate cancer.

John Lin, Caleb Hearn, Emily Getzen, Qi Long, Helayne Drell, David Lee, Tony Keaveny, Ravishankar Jayadevappa, Kyle Robinson, Yu-Ning Wong, Kara Maxwell, Vivek Narayan, Naomi Haas, Samuel Takvorian, Daniel Bikle, Janet Chiang, Amna Khan, Chamith Rajapakse, Alicia Morgans, Ravi Parikh.
Publication Only– Abstract: e24077 

Association of participation in Medicare’s Oncology Care Model with spending, utilization, and quality outcomes among commercially insured and Medicare Advantage members: A national difference-in-differences analysis.

Samyukta Mullangi, Benjamin Ukert, Gosia Sylwestrzak, Andrea DeVries, Stephanie Schauder, Elena Andreyeva, David Debono, Michael Fisch, Stephen Schleicher, Amol Navathe, Aaron Schwartz, Justin Bekelman, Ravi Parikh.
Poster Session: June 5th, 2:15 ET – Abstract: 1596 | Poster: 190 

Evaluating generalizability of practice-changing randomized clinical trials in non-small cell lung cancer using machine learning-based in-silico trials.

Xavier Orcutt, Ronac Mamtani, Arjun Sondhi, Aaron Cohen, Ravi Parikh.
Poster Session: June 4th, 9:00 ET – Abstract: 9130 | Poster: 118 

End-of-life spending analysis of randomized trial of machine learning nudges to prompt serious illness communication among patients with cancer.

Ravi Parikh, Jinbo Chen, Jonathan Heintz, Marc LaPergola, Warren Bilker, Mitesh Patel, Justin Bekelman, Christopher Manz.
Poster Discussion Session: June 3rd, 6:04 ET – Abstract: 6515 | Poster: 7 

Association of remote, longitudinal patient-reported outcomes (PROs) and step counts with hospitalization or death among patients with advanced cancer undergoing chemotherapy: Secondary analysis of the PROStep randomized trial.

Ravi Parikh, Emily Schriver, Joelle Williamson, William Ferrell, Jonathan Wakim, Michael Kopinsky, Mohan Balachandran, Jinbo Chen, Mitesh Patel, Samuel Takvorian, Lawrence Shulman, Justin Bekelman, Ian Barnett, Christopher Manz.
Poster Session: June 5th, 2:15 ET – Abstract: 1581 | Poster: 175 

Implementation strategies for monitoring adherence in real time (iSMART): A pilot randomized trial.

Katharine Rendle, Jocelyn Wainwright, Donna Pucci, Deirdre Yarosh, Christine Cambareri, Linda Jacobs, Abigail Blauch, Abigail Mandel, Caleb Johnston, James Colbert, Bethany Mooney, Justin Bekelman, Stephen Kimmel, Roy Rosin, Lawrence Shulman, E. Paul Wileyto, Sarah Cohen, Charu Aggarwal, Corey Langer, Samuel Takvorian.
Poster Session: June 4th, 9:00 ET – Abstract: 9115 | Poster: 103 

Feasibility of integrating geriatric oncology and palliative care assessment into the routine care of older adults in a community setting.

Ramy Sedhom, Noah Goldman, Kerri Celaya, Kari Mastro, Paul Ortiz, David Dougherty.
Publication Only – Abstract: e24024 

Association between duration of immunotherapy and overall survival in advanced non–small-cell lung cancer.

Lova Sun, Benjamin Bleiberg, Wei-Ting Hwang, Melina Marmarelis, Corey Langer, Aditi Singh, Roger Cohen, Ronac Mamtani, Charu Aggarwal.
Poster Session: June 4th, 9:00 ET – Abstract: 9101 | Poster: 89 

Patient- and clinician-directed implementation strategies to improve serious illness communication for high-risk patients with cancer: A cluster-randomized pragmatic trial.

Samuel Takvorian, Alicia Clifton, Peter Gabriel, E. Paul Wileyto, David Asch, Alison Buttenheim, Katharine Rendle, Rachel Shelton, Oluwadamilola Fayanju, Susan Ware, Lynn Schuchter, Pallavi Kumar, Lawrence Shulman, Tasnim Salam, Daniel Ragusano, Daniel Blumenthal, Justin Bekelman, Rinad Beidas, Robert Schnoll, Ravi Parikh.
Poster Discussion Session: June 5th, 5:42 ET – Abstract: 1514 | Poster 108 

Association between state Medicaid policies and accrual of Black and Hispanic patients to cancer clinical trials.

Samuel Takvorian, William Schpero, Daniel Blickstein, Afrah Shafquat, Jingshu Liu, Arnaub Chatterjee, Elizabeth Lamont, Paula Chatterjee.
Poster Discussion Session: June 5th, 5:30 ET – Abstract: 1510 | Poster: 104 

Real-world use, dose intensity, and adherence to enfortumab vedotin (EV) in locally advanced or metastatic urothelial cancer (la/mUC).

Konstantinos Tsingas, Dina Elsouda, Lisa Mucha, Rupali Fuldeore, Rebecca Hubbard, Ronac Mamtani, Ravi Parikh.
Publication Only – Abstract: e16567 

Racioethnic differences in missing data in the National Cancer Database: A window into inequities in cancer care.

Vignesh Raman, John Migaly, Rachel Greenup, Betty Tong, Oluwadamilola Fayanju.
Publication Only – Abstract: e18502 

Preliminary outcomes of a financial navigation program among lower socioeconomic cancer patients.

Chiu Yi Tan, Jessica Jacoby, Greg Garber, Amy Leader, Rebecca Cammy, Andrea Incudine, Morgan O’Brien, Rosie Cunningham, Thomas Stivers, Meredith Doherty.
Poster Session: June 5th, 2:15 ET – Abstract: 12071 | Poster: 439 

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PC3I Faculty and Fellows also served as co-authors on 31 abstracts:

Oncology Financial Advocacy Services Guidelines: Results of a Delphi study.

Leigh Boehmer, Rifeta Kajdic Hodzic, Allison Harvey, Meredith Doherty, Sharon Gentry, Rebecca Kirch, Krista Nelson, Christina Mangir, Angie Santiago, Lori Schneider, Elana Plotkin.
Publication Only – Abstract: e18606 

Long-term follow-up of “adjuvant” pembrolizumab following locally ablative therapy for oligometastatic non-small cell lung cancer.

David Cantor, Christiana Davis, Christine Ciunci, Charu Aggarwal, Tracey Evans, Evan Alley, Roger Cohen, Joshua Bauml, Corey Langer.
Poster Session: June 4th, 9:00 ET – Abstract: 9061 | Poster: 49 

Real-world comparison of triplet- versus doublet-chemotherapy with bevacizumab in patients with newly diagnosed metastatic colorectal cancer (mCRC).

William Chapin, Wei-Ting Hwang, Ronac Mamtani, Mark O’Hara.
Poster Session: June 5th, 9:00 ET – Abstract: 3574 | Poster: 274 

Patterns of failure in metastatic non-small cell lung cancer (mNSCLC) treated with first line pembrolizumab and use of local therapy in patients with oligoprogression.

Cole Friedes, Nikhil Yegya-Raman, Siqi Zhang, Michelle Iocolano, Roger Cohen, Charu Aggarwal, Jeffrey Thompson, Melina Marmarelis, William Levin, Keith Cengel, Christine Ciunci, Aditi Singh, Christopher D’avella, Christiana Davis, Corey Langer, Steven Feigenberg.
Publication Only – Abstract: e21054 

The COVID-19 pandemic’s impact on diagnosis of cancers detectable through screening.

Carmen Guerra, Peter Gabriel, Abigail Doucette, Colleen Grosso, Armenta Washington, Emily Verderame, Claudia Melendez, Christina Wooden, Daniel Lee, Linda Nunes, Christine Edmonds, Brian Englander, Roderick Brathwaite, Michael Noji, Erin Hollander, Jaia Wingard, Farouk Dako, Corrine Rhodes, Shivan Mehta, Robert Vonderheide.
Publication Only – Abstract: e18669

Electronic health record (EHR) and genomics-based machine learning (ML) to predict therapeutic effectiveness among patients with hormone-receptor positive (HR)+/HER2- advanced breast cancer (aBC).

Deep Hathi, Steven Pisano, Hossein Honarvar, Ravi Parikh, Rahul Das.
Publication Only – Abstract: e13574

Assessment of electronic health record (EHR) –based machine learning (ML) in predicting risk of brain metastasis among patients with early-stage non–small-cell lung cancer (eNSCLC).

Hossein Honarvar, Deep Hathi, Ravi Parikh, Rahul Das.
Poster Session: June 3rd, 2:15 ET – Abstract: 2036 | Poster: 393 

Castration-resistant prostate cancer (CRPC) on PSMA-PET: Imaging features, disease distribution, and a comparison to castration-sensitive prostate cancer (CSPC).

Miles Hsu, Xinhe Shan, Rebecca Zhang, Austin Pantel, Samuel Takvorian, Vivek Narayan, David Vaughn, Neha Vapiwala, Naomi Haas.
Publication Only – Abstract: e17062 

Biochemical recurrence after salvage prostate bed radiotherapy captured on PSMA-PET: Patient characteristics and distribution of recurrent disease.

Miles Hsu, Xinhe Shan, Neha Vapiwala, Rebecca Zhang, Austin Pantel, Eva Berlin, Vivek Narayan, Samuel Takvorian, David Vaughn, Naomi Haas.
Publication Only – Abstract: e17088 

Trends in place of death in adolescents and young adults dying from cancer in the US, 2003-2019.

S. M. Qasim Hussaini, Amanda Blackford, Ramy Sedhom, Arjun Gupta.
Poster Session: June 5th, 2:15 ET – Abstract: 12029 | Poster: 397

Acute hospitalizations after proton beam therapy (PBT) versus intensity-modulated radiotherapy (IMRT) for locally advanced non–small-cell lung cancer (LA-NSCLC) in the era of immune checkpoint inhibitor (ICI) consolidation: A retrospective propensity score weighted study.

Michelle Iocolano, Nikhil Yegya-Raman, Xingmei Wang, Cole Friedes, Sang Ho Lee, Lian Duan, Bolin Li, William Levin, Keith Cengel, Corey Langer, Roger Cohen, Lova Sun, Charu Aggarwal, Abigail Doucette, Ying Xiao, Kevin Teo, Shannon O’Reilly, Jennifer Zou, Charles Simone, Steven Feigenberg.
Poster Session: June 4th, 9:00 ET – Abstract: 8573 | Poster: 200 

Real-world outcomes in patients (pts) with metastatic triple-negative breast cancer (mTNBC) treated with sacituzumab govitecan (SG) in 2L+ in the United States (US).

Kevin Kalinsky, Laura Spring, Clinton Yam, Aliki Taylor, Nikoleta Sjekloca, Alpana Kaushiva, Catherine Lai, Ioanna Ntalla, Rita Nanda
Publication Only – Abstract: e18879 

Association between targeted cancer drug net health benefit and uptake, patient out-of-pocket spending, and total spending.

Kelsey Lau-Min, Yaxin Wu, Shavon Rochester, Justin Bekelman, Genevieve Kanter, Kelly Getz.
Poster Session: June 3rd, 2:15 ET – Abstract: 6644 | Poster: 136 

Palliative care as a component of high-value and cost-saving care during hospitalization for metastatic cancer.

Sifan Lu, Eileen Rakovitch, Breffni Hannon, Camilla Zimmermann, Michael Yan, John de Almeida, Christopher Yao, Erin Gillespie, Fumiko Chino, Divya Yerramilli, Fadwa Abdel-Rahman, Hiba Othman, Sara Mheid, Chiaojung Jillian Tsai.
Poster Session: June 3rd, 2:15 ET – Abstract: 6640 | Poster: 132 

The ticking “biological clock”: Reproductive assistance, costs, and elective fertility preservation in female oncologists and trainees.

Emily MacDuffie, Anna Lee, Aleksandra Kuczmarska-Haas, Shraddha Dalwadi, Erin Gillespie, Michelle Ludwig, Emma Holliday, Fumiko Chino.
Clinical Science Symposium: June 3rd, 5:54 ET – Abstract: 11001 

The effect of ctDNA tumor fraction (TF) on overall survival and concordance between tissue genomics and ctDNA in Lung-MAP.

Philip Mack, Mary Redman, David Kozono, Sam Callis, Hanna Tukachinsky, Khaled Tolba, Joel Neal, Saiama Waqar, Konstantin Dragnev, Charu Aggarwal, Fred Hirsch, Jyoti Patel, Roy Herbst, Anne Chiang, Karen Reckamp, Karen Kelly, Hossein Borghaei, Jhanelle Gray, David Gandara.
Poster Session: June 4th, 9:30 ET – Abstract: 9035 | Poster: 23 

Hematology/oncology program director perspectives on recruitment and inclusion of a diverse workforce.

Ana Velazquez Manana, Dame Idossa, Idalid Franco, Gerald Hsu, Martina Murphy, Evelin Trejo, Jenny Ruiz, Urshila Durani, Maria Garcia-Jimenez, Lachelle Weeks, Ariela Marshall, Narjust Florez, Vonetta Williams.
Poster Discussion Session: June 4th, 12:30 ET – Abstract: 11005 | Poster: 458 

Characteristics of long-term survivors with EGFR mutant (EGFRm) metastatic non-small cell lung cancer (mNSCLC).

Melina Marmarelis, Connor Grady, Caroline McCoach, Fangdi Sun, Geoffrey Liu, Devalben Patel, Jorge Nieva, Kristen Marrone, Vamsidhar Velcheti, Stephen Liu, Tejas Patil, Jared Weiss, William Schwartzman, Liza Villaruz, Amanda Cass, Dara Aisner, Wei-Ting Hwang, Charu Aggarwal, D. Camidge, Lova Sun.
Poster Session: June 4th, 9:00 ET – Abstract: 9116 | Poster: 104 

Racial disparities in utilization of first line targeted therapies for metastatic breast cancer.

Yehoda Martei, Kan Chen, Ronac Mamtani, Lawrence Shulman, Rebecca Hubbard, Amy Clark.
Poster Session: June 3rd, 2:15 ET – Abstract: 6528 | Poster: 20 

Evaluating clinical trial inclusion/exclusion criteria from claims using generative artificial intelligence.

Judith Mueller, Ravi Parikh, Andrew Noble.
Publication Only – Abstract: e13566 

Differences in perceptions and use of remote patient monitoring technology in rural cancer programs.

David Penberthy, Caroline Offit, Christina Mangir, Leigh Boehmer, Bellinda King-Kallimanis, Ramy Sedhom, Cardinale Smith, Smit Patel, Jeffrey Kendall, Jeff Hunnicutt, Amanda Dean Martin, Erin Pierce, Anne Marie Rainey, Adam Dicker, Karen Fecenko-Tacka.
Poster Session: June 5th, 2:15 ET – Abstract: 1582 | Poster: 176 

Electronic health record (EHR)-based machine learning (ML) to predict disease recurrence after surgical resection of early-stage non-small cell lung cancer (eNSCLC).

Steven Pisano, Hossein Honarvar, Ravi Parikh, Rahul Das.
Poster Session: June 3rd, 2:15 ET – Abstract: 6626 | Poster: 118 

A retrospective chart review of palliative care consultation during curative-intent chemoradiation for head and neck cancer.

Farsha Rizwan, Christopher D’avella, Madeline Albert, Traci King, Brian Egleston, Thomas Galloway, Marcin Chwistek, Carolyn Fang, Areej El-Jawahri, Jessica Bauman.
Publication Only – Abstract: e24165 

Multi-center real-world data curation and assessment of tumor growth rate and overall survival in advanced NSCLC treated with PD-(L)1 immune checkpoint inhibitor therapy.

Chiharu Sako, Petr Jordan, Ross McCall, Arpan Patel, Dwight Owen, Arya Amini, An Liu, Brendan Curti, Roshanthi Weerasinghe, Soohee Lee, Ray Page, Aurélie Swalduz, Jean-Paul Beregi, Stéphane Sanchez, Olivier Gevaert, Ravi Parikh, George Simon, Hugo Aerts.
Poster Session: June 4th, 9:00 ET – Abstract: 9124 | Poster: 112 

Racial disparities in germline testing among men with pancreas, breast and metastatic prostate cancers in two health systems.

Jeffrey Shevach, Julie Lynch, Danielle Candelieri-Surette, Rebecca Hubbard, Patrick Alba, Karen Glanz, Ravi Parikh, Kara Maxwell.
Poster Session: June 3rd, 2:15 ET – Abstract: 10549 | Poster 182 

AI-based radiomic biomarkers to predict PD-(L)1 immune checkpoint inhibitor response within PD-L1 high/low/negative expression categories in stage IV NSCLC.

George Simon, Petr Jordan, Chiharu Sako, Ryan Beasley, Dwight Owen, Arpan Patel, Brendan Curti, Roshanthi Weerasinghe, Soohee Lee, Arya Amini, An Liu, Ray Page, Aurélie Swalduz, Jean-Paul Beregi, Stéphane Sanchez, Olivier Gevaert, Ravi Parikh, Hugo Aerts.
Poster Discussion Session: June 5th, 6:04 ET – Abstract: 1517 | Poster: 111 

Homologous recombination deficiency (HRD) in non-small cell lung cancer: Genomic analysis using an RNA-based HRD algorithm.

Stephanie Thiede, Matthew Berginski, Akash Mitra, Timothy Taxter, Michelle Stein, Rotem Ben-Shachar, Halla Nimeiri, Charu Aggarwal, Jyoti Patel.
Poster Session: June 3rd, 9:00 ET – Abstract: 3123 | Poster: 321 

Identifying and addressing barriers to screening mammography in a medically underserved community.

Carla Zeballos Torres, Sara Ginzberg, Julia Gasior, Linda Nunes, Oluwadamilola Fayanju, Brian Englander, Leisha Elmore, Christine Edmonds.
Publication Only – Abstract: e18685 

Impact of pandemic on accrual of minority participants to interventional cancer clinical trials.

Jaia Wingard, Vicki Sallee, Peter Gabriel, Abigail Doucette, Wallace Wormley, Colleen Grosso, Robert Schnoll, Armenta Washington, Daniel Pryma, Katherine Nathanson, Carmen Guerra, Robert Vonderheide.
Publication Only – Abstract: e18581 

Prospective evaluation of cell-free DNA fragmentation profiles for lung cancer detection.

Kwok-Kin Wong, Peter Mazzone, Jun-Chieh Tsay, Harvey Pass, Anil Vachani, Jeffrey Thompson, Allison Ryan, Jacob Carey, Debbie Jakubowski, Tony Wu, Yuhua Zong, Carter Portwood, Keith Lumbard, Joseph Catallini, Kavita Arjungi, Ashley Birch, Alessandro Leal, Peter Bach, Robert Scharpf, Victor Velculescu.
Publication Only – Abstract: e20521 

Phase II trial of consolidation pembrolizumab (pembro) after proton reirradiation (re-RT) for thoracic recurrences of non-small cell lung cancer (NSCLC)

Nikhil Yegya-Raman, Abigail Berman, Christine Ciunci, Xingmei Wang, Cole Friedes, Michelle Iocolano, Ching Lai, William Levin, Keith Cengel, Roger Cohen, Charu Aggarwal, Melina Marmarelis, Aditi Singh, Lova Sun, John Plastaras, Corey Langer, Charles Simone, Steven Feigenberg.
Poster Session: June 4th, 9:00 ET – Abstract: 8552 | Poster: 179 

Additionally, PC3I Faculty will serve as discussants on the following oral abstract and poster discussion sessions: 

No Time to Lose: Early Access to Precision Oncology

Discussant: Charu Aggarwal

Oral Abstract Session: June 6, 11:36 ET