PC3I Presents 32 Abstracts at the 2025 ASCO Annual Meeting
May 30, 2025
This week, oncologists from around the world are gathering to share the latest updates in cutting-edge cancer research at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, IL. This year’s conference theme is Driving Knowledge to Action: Building a Better Future and features 15 first- and senior-authored abstracts, 17 co-authored abstracts, 1 Clinical Science Symposium, and 1 Education Session from Innovation Faculty, Fellows, and staff at the Penn Center for Cancer Care Innovation (PC3I).
PC3I’s work is rooted in delivering equitable and patient-centered care, addressing socioeconomic barriers in oncology, and applying digital interventions to improve patient care and engagement. This year’s innovations include:
- Determining effective strategies to implement the practical geriatric assessment in community practices;
- Educating patients on gynecologic oncology clinical trials through a patient ambassador; and
- Analyzing the relationship between financial toxicity and treatment outcomes during pediatric CAR T therapy.
First- and Senior-Authored Abstracts
Clinician perspectives on digital and computational pathology in oncology: Opportunities and challenges.
Charu Aggarwal, Aakash Desai, Nicholas McConnell, Nicholas Cadirov, Arushi Agarwal, Gary Gustavsen, Srividya Kotapati, Nabil Chehab, Nikunj Patel
Online Publication: Abstract # e15172
KEYMAKER-U01 substudy 01A: Phase 1/2 study of pembrolizumab plus ifinatamab deruxtecan (I-DXd) or patritumab deruxtecan (HER3-DXd) with or without chemotherapy in untreated stage IV non–small-cell lung cancer.
Charu Aggarwal, Tibor Csőszi, Zsuzsanna Szalai, Jair Bar, Nir Peled, Byoung Chul Cho, Yu Jung Kim, Dariusz Kowalski, Ernest Nadal, Jiaxin Niu, Justin Gainor, David Carbone, Konstantin Dragnev, Kevin Chen, David Sternberg, Bin Zhao, Heng Zhou, Azadeh Namakydoust, Vamsidhar Velcheti
Poster Session: May 31, 1:30pm – Abstract # TPS8652 | Poster # 129b
Practical geriatric assessment (PGA) implementation strategies and correlative evaluations (PACE-70): A hybrid implementation-effectiveness study in 3 community practices.
Gabriel Aleixo, Julianne Ani, William Ferrell, Ravi Parikh, Peter Gabriel, Efrat Dotan, Simone Fernandes dos Santos Hughes, Ramy Sedhom, Samuel Takvorian
Poster Session: June 1, 9:00am – Abstract # TPS1661 | Poster # 424b
A mixed method integration of clinician distress typologies in those caring for seriously ill patients within the hospital setting.
Anessa Foxwell, Salimah Meghani, Connie Ulrich, Katherine Courtright
Online Publication: Abstract # e21000
Ten-year patterns of women participating in treatment clinical trials for cancer.
Keshav Goel, Robert Vonderheide, Peter Gabriel, Vicki Sallée, Ariela Marshall
Online Publication: Abstract # e13754
DISCO App: A patient intervention to reduce the financial burden of cancer in a diverse patient population.
Lauren Hamel, David Dougherty, Seongho Kim, Elisabeth Heath, Lorna Mabunda, Teneisha Austin, Hadeel Assad, Hirva Mamdani, Eyouab Tadesse, Roman Grossi, Nouran Jarbo, Susan Eggly
Poster Session: June 1, 9:00am – Abstract # TPS1659 | Poster # 423b
Patients’ digital health needs and the potential impact of a digital health navigator on the oncology care team: Provider and patient perspectives.
Lauren Hamel, Teneisha Austin, Hayley Thompson, Theresa Hastert, Felicity Harper, Ann McAlearney, Eliza Beal
Online Publication: Abstract # e13712
Evaluating a patient ambassador program to improve clinical trial knowledge and intent to discuss gynecologic oncology trials.
Emily Ko, Lakeisha Mulugeta-Gordon, Christine Pae, Destiny Uwawaike, Katie Elkins, Jesse Chittams, Nehemiah Weldeab, Andrea Bilger, Lee Ang, Anna Jo Smith, Carmen Guerra
Poster Session: May 31, 1:30pm – Abstract # 11083 | Poster # 422
Addressing disparities by implementing a supportive care program in oncology.
Emily Ko, Camille McCallister, Katie Elkins, Nehemiah Weldeab, Nathanael Koelper, Jesse Chittams, Stefanie Hinkle, Allan Huang, Kristina Powell, Mary Pat Lynch, Megan Wachlin, Heidi Harvie, Sarah Kim, Mary Boland, Anna Jo Smith
Poster Session: May 31, 1:30pm – Abstract # 11082 | Poster # 421
Real-world enfortumab vedotin +/- pembrolizumab (EV+/-P)–based treatment toxicity, treatment discontinuation, and associations with survival in advanced urothelial carcinoma (aUC).
Martin Kurian, Vivek Nimgaonkar, Omar Elghawy, Ronac Mamtani
Poster Session: June 2, 9:00am – Abstract # 4562 | Poster # 362
Advancing global equity in cancer care: Comparative environmental impacts of radiotherapy in Brazil and the U.S.
Katie Lichter, Genevieve Silva, Samuel Avelino, Chirjiv Anand, Osama Mohamad, Shearwood McClelland III, Katherine Van Loon, Surbhi Grover
Poster Session: June 1, 9:00am – Abstract # 1627 | Poster # 393
Clinical utility and cost-effectiveness of a molecular biomarker for immune checkpoint inhibitor response monitoring and treatment decisions.
Zachary Rivers, Akash Mitra, Victoria Chiou, Halla Nimeiri, Sheetal Kircher, David Stenehjem, Rotem Ben-Shachar, Charu Aggarwal
Online Publication: Abstract # e23338
Gynecologic oncology referral rates of adnexal masses suspicious for ovarian cancer in an academic health system: A cohort study.
Anna Jo Smith, Sarah Bell, Tessa Cook, Shivan Mehta, Charlie Chambers, Hanna Zafar, Lisa Jones, Lin Xu, Justin Bekelman, Anne Marie McCarthy, Elizabeth Howell
Poster Session: June 1, 9:00am – Abstract # 5544 | Poster # 442
EMBER-Lung: Electronic medical record boosting molecular testing in early stage NSCLC.
Willdragon Wang, Dylan Scholes, Megan Roy, Sunil Singhal, John Kucharczuk, Doraid Jarrar, Jarrod Predina, Taine Pechet, Lova Sun, Aditi Singh, Roger Cohen, Corey Langer, Charu Aggarwal, Melina Marmarelis
Poster Session: May 31, 1:30pm – Abstract # 8075 | Poster # 196
Financial toxicity and association with treatment outcomes during pediatric CAR T therapy.
Daniel Zheng, Lei Wang, Kelly Getz, Richard Aplenc, Kerry Coughlin, Amanda DiNofia, Shannon Maude, Regina Myers, Haley Newman, Taylor Orsini, Donnette Paris, Stephan Grupp, Allison Barz Leahy
Poster Session: May 31, 9:00am – Abstract # 10028 | Poster # 143
PC3I Faculty and Fellows also served as co-authors on several abstracts:
Survival after osimertinib dose-reduction, discontinuation in 1L EGFR-mutated metastatic non-small cell lung cancer (mNSCLC).
Adam Barsouk, Omar Elghawy, Austin Yang, Alec Heidlauf, Connie Yu, David Yang, Lucy Wang, Martin Kurian, Keshav Goel, Lynn Rushkin, Anran Huang, Lauren Reed-Guy, Benjamin Bleiberg, Lova Sun, Aditi Singh, Roger Cohen, Charu Aggarwal, Melina Marmarelis, Corey Langer
Poster Session: May 31, 1:30pm – Abstract # 8587 | Poster # 67
Histopathologic and demographic features of non-small cell lung cancer in patients with BRCA pathogenic germline variants.
Benjamin Bleiberg, Michael Wang, Caitlin Orr, Katie Cappola, Abigail Doucette, Heena Desai, Ryan Hausler, Bradley Wubbenhorst, Peter Gabriel, Kate Nathanson, Andrew Haas, Melina Marmarelis, Susan Domchek, Kara Maxwell
Poster Session: May 31, 1:30pm – Abstract # 10573 | Poster # 298
The eREACH study: A randomized study of an eHEALTH delivery alternative for cancer genetic testing for hereditary predisposition in patients with metastatic cancers.
Angela Bradbury, Brian Egleston, Sarah Brown, Briana Mcleod, Dominique Fetzer, Cara Cacioppo, Janice Christiansen, Dana Farengo-Clark, Susan Domchek, Jessica Ebrahimzadeh, Linda Fleisher, Sarah Howe, Kelsey Karpink, Kimberley Lee, Enida Selmani, Lynne Wagner, Michelle Weinberg, Kuang-Yi Wen, Elisabeth Wood
Oral Abstract Session: June 2, 11:54am – Abstract # 10502
Equivalence of Ina, an AI-based nutrition platform, to human dietitians for counseling patients with cancer.
Marissa Buchan, Melanie Guirette, Nancy Buderer, Ethan Basch, Chelsey Schneider, Keshav Goel, Susan Bratton, Stacy Loeb
Poster Session: June 2, 1:30pm – Abstract # 12117 | Poster # 137
A cluster analysis of clinician distress trajectories when caring for seriously ill hospitalized patients.
Anessa Foxwell, Connie Ulrich, Salimah Meghani, Katherine Courtright, Liming Huang, Janet Deatrick, Karen Hirschman, Joseph Rhodes
Poster Session: June 2, 1:30pm – Abstract # 9012 | Poster # 1
First accounting of comprehensive radiotherapy life cycle assessment components in Africa.
Phylicia Gawu, Charles Akoto-Aidoo, Isaac Washburn, Katie Lichter, Idalid Franco, Jerry Jaboin, Aba Scott, Meritxell Mallafré-Larrosa, Alfredo Polo, Osama Mohamad, Surbhi Grover, Verna Vanderpuye, Shearwood McClelland III
Online Publication: Abstract # e23213
V-RULES: Real-world effectiveness and safety of CPX-351 in patients with secondary acute myeloid leukemia (AML).
Thomas LeBlanc, Catherine Lai, Amir Ali, Onyee Chan, Doria Cole, Jesus Gonzalez Lugo, Kristin Koenig, Mimi Lo, Matthew Newman, Saemi Park, Giuseppe Piccoli, Charlotte Wagner, Amanda Lopez, George Yaghmour, Eunice Wang
Poster Session: June 1, 9:00am – Abstract # 6520 | Poster # 136
Patterns of immunotherapy use in dMMR/MSI-H metastatic CRC.
Hayley Lemisch, Li Zhang, Jill Hasler, Efrat Dotan, Vanessa Wookey
Poster Session: May 31, 9:00am – Abstract # 3557 | Poster # 226
Machine learning–informed navigation of patients in persistent poverty zip codes to improve colorectal cancer screening: A prospective controlled study.
Ravi Parikh, Caleb Hearn, Yvette Frimpong, Yang Li, Keshav Goel, Jessica Ferber, Kara Berwanger, Diann Boyd, Carmen Guerra
Poster Session: May 31, 1:30pm – Abstract # 10539 | Poster # 264
Effect of human-AI teams on oncology prescreening: Final analysis of a randomized trial.
Ravi Parikh, Likhitha Kolla, Elizabeth Beothy, William Ferrell, Brenda Laventure, Matthew Guido, Anthony Girard, Yang Li, Jinbo Chen, Ezekiel Emanuel
Oral Abstract Sesssion: June 2, 5:12pm – Abstract # 1508
Sequential EHR interventions to increase genetic testing for breast and ovarian cancer predisposition across diverse patient populations in gynecology practices at Penn Medicine.
Heather Symecko, Daniel Blumenthal, Leland Boisseau, Susan Ware, Elizabeth Clement, Ryan Offer, Martina Plag, Peter Gabriel, Katharine Rendle, E. Paul Wileyto, Rinad Beidas, Justin Bekelman, David Asch, Alison Buttenheim, Robert Schnoll, Katherine Nathanson, Susan Domchek
Poster Session: May 31, 1:30pm – Abstract # 10589 | Poster # 314
Mammography results in male BRCA carriers.
Maliha Tayeb, Caitlin Orr, Roukiatou Sore, Meredith Davies, David Lu, Heather Symecko, Sarah Ehsan, Heena Desai, Ryan Hausler, Bradley Wubbenhorst, Abigail Doucette, Peter Gabriel, Katherine Nathanson, Christine Edmonds, Susan Domchek, Anne Marie McCarthy, Kara Maxwell
Poster Session: May 31, 1:30pm – Abstract # 10618 | Poster # 343
Comparison of mobile mammography versus urban hospital-based breast cancer screening.
Carla Zeballos Torrez, Christine Edmonds, Brian Englander, Linda Nunes, Amissa Brewer-Hofmann, Stephany Perez-Rojas, Jiarui Yan, Oluwadamilola Fayanju, Leisha Elmore
Poster Session: June 1, 9:00am – Abstract # 1605 | Poster # 371
Use of targeted therapy in patients with advanced non-small cell lung cancer in response to broad genomic profiling.
Xiao Wang, Jessica Long, John Rothen, Sida Huang, Pamela Soulos, Timothy Robinson, Carolyn Presley, Sarah Goldberg, Ronac Mamtani, Steven Ma, Shi-Yi Wang, Natalia Kunst, Michaela Dinan, Cary Gross
Poster Session: May 31, 1:30pm – Abstract # 11155 | Poster # 494
Real-world patient management practices in responders to venetoclax for newly diagnosed acute myeloid leukemia.
Ofir Wolach, Pinkal Desai, Evan Chen, Joshua Zeidner, Thomas LeBlanc, Sameem Abedin, Pankit Vachhani, Kendra Sweet, Yakir Moshe, Daniel Pollyea, Catherine Lai, Marina Konopleva, Boaz Nachmias, Lee Mozessohn, Marin Xavier, Tsila Zuckerman, Yanqing Xu, Chia-Wei Lin, Rebecca Burne, Aaron Goldberg
Poster Session: June 1, 9:00am – Abstract # 6527 | Poster # 143
Career transitions and practice patterns among international medical graduates in oncology workforce: A US nationwide analysis.
Jiazhang Xing, Qian Wang, Yixin Tang, Chuan Lu, Fangyuan Chen, Arya Mariam Roy, Lei Deng, Karun Neupane, Fatemeh Ardeshir Larijani, Tanios Bekaii-Saab, Charu Aggarwal, Alfred Lee, Taofeek Owonikoko, Mariana Chavez Mac Gregor, Ziad Bakouny, Shipra Gandhi, Nazli Dizman, Toni Choueiri, Stuthi Perimbeti, Changchuan Jiang
Rapid Oral Abstract: June 2, 10:45am – Abstract # 9009
Caregiver distress: Caring for those who care for our patients.
Abigail Zamorano, Joe Haydamous, Jorge Cervantes, Anna Brown, Anna Jo Smith, Shearwood McClelland III, Joseph Lucci, Elizabeth Nugent, Rosa Guerra, Lavanya Palavalli Parsons, Diego Aviles, Judith Smith, Jose Alejandro Rauh-Hain
Poster Session: May 31, 1:30pm – Abstract # 11115 | Poster # 454
Other Sessions:
Special Populations: Optimizing Perioperative Management Strategies in Patients With EGFR Mutations
Session: Genomic Insights in Perioperative Decision-Making in Non–Small Cell Lung Cancer: Navigating EGFR, ALK, and Emerging Biomarkers
Chair: Charu Aggarwal
Education Session: June 3, 8:00am
Analysis of evidence in NCCN harmonized guidelines for sub-Saharan Africa.
Scott Swartz, Samrawit Agezew, Ayo Falade, Rebecca DeBoer, Mary Jue Xu, Glory Makupa, Eulade Rugengamanzi, Courtney Chau, Kathy Jung, Rohan Luhar, Pariswi Tewari, Alita Mrema, Katherine Van Loon, Geoffrey Buckle, Gwynn Spielman
Clinical Science Symposium: June 2, 8:00am – Abstract # 1510
