PC3I Presents 50 Abstracts at the 2026 ASCO Annual Meeting

May 28, 2026

This week, oncologists from around the world are gathering to share the latest updates in cutting-edge cancer research at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, IL. This year’s conference theme is “The Science and Practice of Translation: Improving Cancer Outcomes Worldwide” and features 25 first- and senior-authored abstracts, 25 co-authored abstracts, and 4 special sessions from Innovation Faculty, Fellows, and staff at the Penn Center for Cancer Care Innovation (PC3I).

PC3I’s work is rooted in delivering equitable and patient-centered care, addressing socioeconomic barriers in cancer care, and implementing sustainable interventions to improve patient care and engagement. This year’s innovations include:

Testing an alternative eHealth method of genetic testing for hereditary cancer;
Assessing patient engagement with an oncology chatbot; and
Understanding the unmet needs of survivors of ovarian cancer.

*All times listed below are in CDT*

First- and Senior-Authored Abstracts

Real-world treatment patterns and outcomes with olutasidenib after venetoclax in IDH1-mutated AML using EHR data.

Yasmin Abaza; Pinkal M. Desai; Jorge E. Cortes; Timothy Werwath; Amber Thomassen; Aaron D. Sheppard; Catherine Lai

Publication Only: Abstract #e18514

Correlative analysis between external and internal lymphedema in head and neck cancer survivors.

Jessica Abene; Barbara Murphy; Mary S. Dietrich; Jie Deng

Poster Session: May 30, 1:30pm – Abstract #12120 | Poster #103

Sotorasib vs adagrasib in the 2L+ setting: Outcomes in a large, multi-institutional, real-world database of KRAS-G12C mutated mNSCLC.

Adam Barsouk; Maxim Yaskolko; Jonathan H. Sussman; Lova Sun; Roger B. Cohen; Charu Aggarwal; Corey J. Langer; Melina E. Marmarelis

Poster Session: May 31, 9:00am – Abstract #8608 | Poster #398

Structured exercise program following adjuvant chemotherapy for colon cancer: A cost-utility analysis of the CHALLENGE trial.

Kelvin K. Chan; Ryan W. Chu; Matthew C. Cheung; Kerry S. Courneya; Christopher J. O’Callaghan; Janette L. Vardy; Sharlene Gill; Christine Friedenreich; Rebecca K. Wong; Haryana M. Dhillon; Vicky Coyle; Neil S. Chua; Derek J. Jonker; Ralph M. Meyer; Shahid Ahmed; John R. Zalcberg; Stephen J. Clarke; Patti O’Brien; Dongsheng Tu; Christopher M. Booth

Oral Abstract Session: May 31, 10:12am – Abstract #3507

Incidentally discovered lung cancer in explanted lungs at the time of lung transplantation: Management and outcomes.

Rachel Jaber Chehayeb; Willdragon Wang; Lova Sun; Aditi P. Singh; Roger B. Cohen; Corey J. Langer; Charu Aggarwal; Melina E. Marmarelis

Publication Only: Abstract #e20087

Digital twin models for counterfactual prediction in NSCLC: A validation study using clinical trial data.

Aaron B. Cohen; Sandra Griffith; Melissa Estevez; Brandon Arnieri; Matthew H. Secrest; Joseph Manfredonia; Marcello Ricottone; Richard Knoche; Jacqueline Law; Melina E. Marmarelis

Publication Only: Abstract #e20517

Clinical presentation, management strategies, and recurrence rates in vulvar intraepithelial neoplasia (VIN) globally: A systematic review.

Elizabeth Corn; Sierra Silverwood; Isabela Anawate; Gauthami Moorkanat; Surbhi Grover

Publication Only: Abstract #e17649

Sharing geriatric and functional status assessment data with older adults who have cancer: Patients’ preferences and utility.

Zachary Frosch; Gerald Nkogbu; Leslie Fortin; Li Zhang; Michael J. Hall; Vanessa Wookey; Lindsey Taylor; Matthew R. Zibelman; Christopher G. Cann; Dina Ioffe; Teresa Lee; Marcus Messmer; Shazia Nakhoda; Carolyn Y. Fang; Efrat Dotan

Publication Only: Abstract #e13761

Prospective prostate cancer screening in germline pathogenic variant carriers: The PATROL study.

Daniel Lee; Caitlin Orr; Evelyn Milavsky; Andrew Amini; Christopher L. Amling; Kristin Follmer; Grace Jun; Chenee Holcomb; Maxwell Poole; Linda Rodgers; Hiten D. Patel; Matthew R. Cooperberg; Joanne M. Jeter; Alexandra Sokolova; Keyan Salari; Kara N. Maxwell; Heather H. Cheng; Daniel W. Lin

Oral Abstract Session: June 2, 11:09am – Abstract #10505

BCG at home: A first-in-kind pilot trial of home-based intravesical Bacillus Calmette-Guérin delivery for high-risk non-muscle-invasive bladder cancer.

Daniel Lee; Scott A. Soefje; Danielle Fidyk; Stephanie Kessler; Lindsay Northern; Alexander Radovanovich; David Kim; Donna Cappozzi; Aquilla Obare; Hanna Stambakio; Shirley Wang; Thomas Guzzo; Trinity Bivalacqua

Publication Only: Abstract #e13615

A randomized non-inferiority trial of an eHealth delivery alternative for cancer genetic testing for hereditary cancer (eREACH2).

Kimberley T. Lee; Brian L. Egleston; Dominique Fetzer; Sarah Brown; Susan M. Domchek; Linda Fleisher; Kuang-Yi Wen; Lynne I. Wagner; J. Scott Roberts; Cara Cacioppo; Janice Christiansen; Sarah Howe; Elisabeth Wood; Michelle Weinberg; Kelsey Karpink; Enida F. Selmani; Justin Feng; Samantha John; Evelyn Mastaglio; Angela R. Bradbury

Rapid Oral Abstract Session: May 31, 9:51am – Abstract #10510

Multi-center prospective study evaluating an AI-enabled clinical decision support tool to improve biomarker testing in early-stage NSCLC.

Melina E. Marmarelis; Jessica Dow; Journey Penney; Binyam Yilma; Alexis Aiello; Marina Codari; Chithra Sangli; Karen Huelsman; Andrew J. Parchman; Charu Aggarwal; Sarah G. Thompson; Natraj R. Ammakkanavar; George R. Simon; Amol Rao; Gautum Agarwal; Ezra E. Cohen; Jyoti D. Patel; Noah Zimmerman

Poster Session: May 31, 9:00am – Abstract #8044 | Poster Bd # 518

Untreated advanced urothelial carcinoma (aUC) in the modern treatment era: Patterns of care from a decade-long national cohort.

Melanie Mayer; Nicholas Seewald; Aram Babcock; Blanca Homet Moreno; Chethan Ramamurthy; Haojie Li; Ronac Mamtani

Poster Session: May 31, 9:00am – Abstract #4570 | Poster #49

Rethinking MRI surveillance after breast cancer in the context of persistent racial disparities in mortality.

Elizabeth S. McDonald; Nathaly Perez Rojas; Hayat Naqvi; Peter R. Eby; Anne Marie McCarthy

Poster Session: May 30, 9:00am – Abstract #1675 | Poster #593

Volrustomig, a novel bispecific PD-1/CTLA-4 monoclonal antibody, as single-agent first-line therapy for unresectable pleural mesothelioma: Substudy 5 of the eVOLVE-02 phase 2 study.

Michael Offin; Xiaoling Zeng; Shenqi Wang; Bingying Xie; Melina E. Marmarelis

Poster Session: May 31, 9:00am – Abstract #TPS8126 | Poster #598b

From Air to Awareness: Pollution and the Path to Early Detection

Katharine Rendle

Oral Abstract Session: June 1, 2:39pm

The association of IDH co-mutations with treatment outcomes and overall survival in TP53-mutated acute myeloid leukemia.

Lukas Ronner; Sarah J. Skuli; Andrew Matthews; Catherine Lai

Poster Session: June 1, 9:00am – Abstract #6520 | Poster #313

Beyond survival: Understanding unmet needs among a diverse cohort of ovarian cancer survivors.

Caroline P. Shermoen; Anne Marie McCarthy; Katie Elkins; Tyasia Cannon; Chelsea Peart; Mlka Mengesha; Karen Glanz; Anna Jo B. Smith; Emily M. Ko

Poster Session: June 1, 9:00am – Abstract #5578 | Poster #244

An EHR-embedded SmartForm (OncAssessment) paired with ePROs to enable real-time structured documentation of key oncologic data during routine cancer care: A pragmatic implementation study.

Aditi P. Singh; Kate Barbour; Christiana Davis; Daniel Huth; Willdragon Wang; Peter Gabriel; Victoria Wang; Charu Aggarwal; Peter J. O’Dwyer; Mitchell Schnall; Sabrina Meyers; Lawrence N. Shulman; Cosmina Hogea

Poster Session: May 30, 9:00am – Abstract #TPS1682 | Poster # 597a

Sensitivity of CA-125 by ovarian cancer histology.

Anna Jo B. Smith; Camille McCallister; Xingmei Wang; Chelsea Peart; Elizabeth A. Howell; Anne Marie McCarthy

Publication Only: Abstract #e17557

Understanding patient engagement with an oncology chatbot: Thematic and sentiment analysis of medical adherence.

Weilu Song; Chelsea Saia; Jocelyn Wainwright; Jillian Kalman; Hannah Toneff; Samuel U. Takvorian; Katharine A. Rendle

Publication Only: Abstract #e13705

Gaps in patient-facing information on artificial intelligence in cancer care: A cross-sectional analysis.

Pearl Subramanian; Suditi Shyamsunder; Khashayar Eshaghi; Ronac Mamtani; Henry K. Litt

Clinical Science Symposium: May 31, 9:57am – Abstract #9000

Long-term ctDNA reassessment (LTctDNA) in NSCLC immunotherapy responders.

Lova Sun; Willdragon Wang; Kyle Chang; Leslie A. Bucheit; Keelia Clemens; Aditi P. Singh; Melina E. Marmarelis; Roger B. Cohen; Corey J. Langer; Charu Aggarwal

Publication Only: Abstract #e20539

SPARK-Lung: A study of patterns and outcomes in young-onset lung cancer.

Teja Voruganti; Yi Lian; Benjamin A. Bleiberg; Lauren Reed-Guy; Roger B. Cohen; David J. Cantor; Kyle W. Robinson; Christopher D’Avella; Christine A. Ciunci; Melina E. Marmarelis; Aditi P. Singh; Corey J. Langer; Lova Sun; Charu Aggarwal

Poster Session: May 31, 9:00am – Abstract #8070 | Poster Bd # 544

The real-world outcomes from late-line chemotherapy for advanced colorectal cancer: A population-based analysis of attrition rates, outcomes, and health care contact in a single-payer health system.

Brooke Wilson; Nan Chen; Arjun Gupta; Shaila J. Merchant; Rachel Koven; Timothy P. Hanna; Christopher M. Booth

Publication Only: Abstract #e23443

PC3I Faculty and Fellows also served as co-authors on several abstracts:

The impact of body composition on cardiac function in women with early breast cancer taking cardiotoxic chemotherapy.

Gabriel Aleixo; Wei-Ting Hwang; Ramy Sedhom; Rakesh Sharma; Wonyoung Jung; Congying Xia; Walter Witschey; Bonnie Ky

Poster Session: May 30, 1:30pm – Abstract #12021 Poster #4

Long-term survival outcomes of consolidative local ablative therapy after response to first-line systemic treatment in oligometastatic NSCLC.

Phurin Areesawangkit; Adam Barsouk; Maxim Yaskolko; Lucy Wang; Cole Friedes; Roger B. Cohen; Lova Sun; Charu Aggarwal; Melina E. Marmarelis; Aditi P. Singh; Kyle W. Robinson; Christopher D’Avella; Christine A. Ciunci; Steven J. Feigenberg; Jeffrey D. Bradley; Nikhil Yegya-Raman; Michelle Iocolano; Christiana Davis; Corey J. Langer

Poster Session: May 31, 9:00am – Abstract #8601 | Poster #391

Performance status and tarlatamab outcomes in a large, multi-institution real-world database of 2L+ ES-SCLC.

Adam Barsouk; Jonathan H. Sussman; Maxim Yaskolko; Lova Sun; Aditi P. Singh; Charu Aggarwal; Roger B. Cohen; Melina E. Marmarelis; Corey J. Langer

Publication Only: Abstract #e20120

From plenary to practice: A large language model (LLM)–based thematic analysis of landmark clinical trial discussions and factors influencing their real-world adoption.

Aaron B. Cohen; Tori Williams; Charu Aggarwal; Angela DeMichele; Ritvik Vasudevan; Niquelle Wadé; Shreya Balakrishna Rosseau; Erin Fidyk; Blythe J. Adamson

Poster Session: May 30, 9:00am – Abstract #1583 | Poster #501

Assessing the clinical utility of MRI for preoperative staging of early-stage cervical cancer in a limited-resource setting: A retrospective study from Botswana.

Elizabeth Corn; Kelly Becht; Bethel Adefres; Barati Monare; Rebecca Ketlametswe; Leatile Sedabadi; Juan Ariel Oliva Díaz; Peter Vuylsteke; Surbhi Grover; Lisa Bazzett-Matabele

Publication Only: Abstract #e17502

Mammography utilization and male breast cancer in BRCA1/2 carriers.

Meredith Davies; Maliha Tayeb; Jasmine Phun; Emily Scarrow; Evelyn Milavsky; Caitlin Orr; Roukiatou Sore; Heather H. Symecko; Sarah Ehsan; Heena Desai; Abigail Doucette; Peter Gabriel; Christine E. Edmonds; Susan M. Domchek; Isla Garraway; Martin W. Schoen; Anne Marie McCarthy; Jennifer Zhang; Kara N. Maxwell

Poster Session: June 1, 1:30pm – Abstract #10563 | Poster #524

Treatment patterns and outcomes with olutasidenib after venetoclax in IDH1-mutated AML using real-world data from a chart review.

Pinkal M. Desai; Catherine Lai; Ashwin Kishtagari; Namrata S. Chandhok; Timothy S. Pardee; Amber Thomassen; Aaron D. Sheppard

Publication Only: Abstract #e18527

Utilization patterns and disparities in supportive oncology services for patients with stage IV non-small cell lung cancer.

Rebekah S. Feld; Luxiga Thanabalachandran; Daniel Jafari; Wilma M. Hopman; Weidong Kong; Alyson L. Mahar; Christopher M. Booth; Yuchen Li

Publication Only: Abstract #e20649

Histomics as an emerging avenue for oncology biomarker development: Computational Histology Artificial Intelligence (CHAI) analysis of The Cancer Genome Atlas (TCGA).

Richard M. Goldberg; Neeraj Agarwal; Sumanta K. Pal; Vrishab Krishna; Viswesh Krishna; Gaurav Kaul; Akshay Neema; Asit Tarsode; Haochen Zhang; Ekin Tiu; Lesli A. Kiedrowski; Trevor Royce; Anirudh Joshi; Charu Aggarwal; Sue S. Yom; Lin Shen; Andrew Hendifar; Eric A. Collisson; Ashish M. Kamat; John M. Kirkwood

Publication Only: Abstract #e15008

Final analysis of the biomarker-directed, randomized, phase 2 KEYNOTE-495/KeyImPaCT study of pembrolizumab (P)–based combination therapy for non–small cell lung cancer (NSCLC).

Martin Gutierrez; Wei-Sen Lam; Adam J. Schoenfeld; Matthew A. Gubens; Charu Aggarwal; Daniel S. Tan; Enriqueta Felip; Joanne W. Chiu; Jong-Seok Lee; James Chih Hsin Yang; Edward B. Garon; Giovanna Finocchiaro; Miaojun Han; Julie Kobie; John Palcza; E.J. Dettman; Lawrence Fong; Jianda Yuan; Bin Zhao; Roy S. Herbst

Poster Session: May 31, 9:00am – Abstract #8584 | Poster #374

DISCO app: Feasibility and acceptability of an intervention to reduce the financial burden of cancer in a diverse patient population.

Lauren M. Hamel; David W. Dougherty; Seongho Kim; Elisabeth I. Heath; Lorna Mabunda; Teneisha Austin; Hadeel Assad; Hirva Mamdani; Mohammed N. Al Hallak; Helda Bacall; Adrienne Bouyer; Frank C. Cackowski; Radhika Gogoi; Erica Goldman; Ira S. Winer; Eliza W. Beal; Nouran Jarbo; Keri Angers; Susan Eggly

Publication Only: Abstract #e13729

Patient correlates of patient-provider communication and financial toxicity in Black and White patients with cancer.

Publication Only: Abstract #e13730

Closing the depression gap in community oncology: Real-world outcomes from collaborative care.

Tyler Jones; Elizabeth Cleary; Cameron Schilling; Casey Patterson; Ramy Sedhom; Jesse R. Fann

Poster Session: May 30 1:30pm – Abstract #12088 | Poster #71

Health technology agencies’ reimbursement decisions for cancer drugs across four high‑income countries.

Mina Jordanides; Sophie Keith-Brown; Kristina Jenei; Samuel X. Stevens; Evelyn Wong; Deme J. Karikios; Christopher M. Booth; Brooke Wilson

Publication Only: Abstract #e23037

Association of GLP-1 agonists with breast cancer incidence in women.

Elizabeth S. McDonald; Laura Gillis; Peter Gabriel; Kham Xapakdy; Anthony J. Young; Mitchell D. Schnall; Etta Pisano

Oral Abstract Session: June 2, 11:45am – Abstract #10506

Overall survival of first-line amivantamab plus lazertinib in atypical EGFR-mutated advanced non-small cell lung cancer (NSCLC): Updated results from the CHRYSALIS-2 study.

Joel W. Neal; Byoung Chul Cho; Yongsheng Wang; Lin Wu; Enriqueta Felip; Jiuwei Cui; Alexander I. Spira; Melina E. Marmarelis; Eiki Ichihara; Se-Hoon Lee; James Chih Hsin Yang; Sebastian Y. Michels; Joshua C. Curtin; Xuesong Lu; Zacharias Anastasiou; Isabelle Leconte; Leonardo Trani; Sujay Shah; Pascale Tomasini

Oral Abstract Session: May 29, 1:12pm – Abstract #8501

Evaluation and appraisal of quality indicators for end-of-life cancer care in an African context.

Vivens Nsabimana; Jordana Avigad; Olive Mukeshimana; Francois Sebishyimbo; Sarah Slater; Alexandra Fehr; Adolphe Muhire; James Ntambara; Musafiri Tumusime; Lawrence N. Shulman; Cyprien Shyirambere; Eulade Rugengamanzi; Rebecca J. DeBoer

Rapid Oral Abstract Session: May 29, 3:21pm – #Abstract 1517

Machine learning risk stratification in a US-based database to identify subgroups of patients with head and neck cancer who benefit from adding chemotherapy to pembrolizumab.

Xavier Orcutt; Vivek Nimgaonkar; Lova Sun; Charu Aggarwal; Aaron B. Cohen; Ronac Mamtani; Qi Long; Ravi B. Parikh

Publication Only: Abstract #e18007

Machine learning risk stratification in a US-based database to identify subgroups of patients with PD-L1-high NSCLC who benefit from adding chemotherapy to pembrolizumab.

Xavier Orcutt; Vivek Nimgaonkar; Lova Sun; Charu Aggarwal; Aaron B. Cohen; Ronac Mamtani; Qi Long; Ravi B. Parikh

Publication Only: Abstract #e20523

Efficacy and tolerability of duvelisib in relapsed/refractory peripheral T-cell lymphoma: A multicenter real-world analysis.

Priyanka Pullarkat; Kishan K. Patel; Alison J. Moskowitz; Omar Elghawy; Stefan K. Barta; Josie Ford; Salvia Jain; Lauren Shea; Shambhavi Singh; Jie Wang; Fatima Tuz Zahra; Yumeng Zhang; Neha Akkad; Swaminathan P. Iyer; Alexander D. Sanjurjo; Seda S. Tolu; Matthew A. Lunning; Bret Wankel; Conner Liddle; Neha Mehta-Shah

Poster Session: June 1, 9:00am – Abstract #7067 | Poster #565

Impact of neoadjuvant immunotherapy on safety of axillary de-escalation in triple-negative breast cancer (TNBC): A propensity score–matched analysis.

Zheng Qu; Zheng Li; Hongzhe Zhang; Jennifer Q. Zhang; Oluwadamilola M. Fayanju; Yi Fang

Publication Only: Abstract #e12674

A prospective trial of single-dose neoadjuvant PD-1 blockade with or without a CD40 agonist in HPV-negative HNSCC.

Lova Sun; Max M. Wattenberg; Devora Delman; Kelly Markowitz; Jalal Jalaly; Devraj Basu; Robert Brody; Gregory S. Weinstein; Steven Cannady; James Gates; Karthik Rajasekaran; D Gregory Farwell; Ryan Carey; Ara Chalian; Christopher Rassekh; Aditi P. Singh; E. Paul Wileyto; Roger B. Cohen; Gregory L. Beatty

Poster Session: May 30, 1:30pm – Abstract #6087 | Poster #544

Using the NCCN distress thermometer to evaluate clinically elevated levels of distress among caregivers of HSCT patients.

Christine Vinci; Steve Sutton; Marilyn Horta; Ranjita Poudel; Min-Jeong Yang; Maija Reblin; Joseph A. Pidala; Heather S. Jim; Sierra Washington; Halle Smith

Poster Session: May 30, 1:30pm – Abstract #12093 | Poster #76

Designing a solid tumor oncology curriculum for medical residents: A single-institution needs assessment.

Anna Wing; Ronac Mamtani; Ronak Mistry

Publication Only: Abstract #e21011

The impact of online CME on addressing clinical decision-making for immunotherapy in advanced squamous NSCLC.

Michelle A. Worst; Andrew Small; Amy Furedy; Charu Aggarwal; Sandip P. Patel

Publication Only: Abstract #e21002

Other Sessions:

Genitourinary Cancer – Kidney and bladder

Session Chair: Ronac Mamtani

Oral Abstract Session: May 29, 2:45pm

Lung Cancer—Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers

Session Chair: Melina Marmarelis

Rapid Oral Abstract Session: May 31, 4:30pm

Trials, Endpoints, and the Hippocratic Oath: Providing Care That Matters

Session Presenter: Christopher Booth

Education Session: May 31, 4:30pm

Innovation, Evidence, Compassion, and Hope: Delivering Outcomes That Matter

Session Chair: Christopher Booth