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PC3I Presents 19 Abstracts at ASCO 2021

The 2021 American Society of Clinical Oncology (ASCO) Annual Meeting will bring together oncologists from around the world to share the latest cutting-edge research under the theme Equity: Every Patient. Every Day. Everywhere. Taking place online June 4-8, the Annual Meeting will feature 19 abstracts from Innovation Faculty and Fellows at the Penn Center for Cancer Care Innovation (PC3I).

PC3I faculty and fellows will present data from studies ranging from experimental health services research to analyses of real-world data. They share findings from across the cancer care continuum, such as strategies to improve lung cancer screening rates, increase access to groundbreaking CAR-T therapy, and reduce high-intensity end-of-life care for patients with gynecologic cancer. Several projects focus on innovative ways Penn Medicine supported patients and adapted systems during the pandemic, such as the development of a remote symptom monitoring tool for patients with cancer and COVID-19. Others at the intersection of behavioral economics and machine learning investigate ways to predict outcomes and improve care. Throughout, PC3I faculty and fellows highlight opportunities to elevate health equity and tackle disparities.

All 19 abstracts are listed below, with poster discussions and sessions, oral abstract sessions, and clinical science symposiums taking place throughout the Annual Meeting.


The national impact of the COVID-19 pandemic on U.S. prostate cancer community care.

Matthew R. Cooperberg, Paul Brendel, Daniel J. Lee, Rahul Doraiswami, Hariesh Rajasekar, Danil V. Makarov, William Meeks, Raymond Fang, Matthew T Roe, Jeremy B. Shelton.
Watch the Poster Session here.

Cancer COVID Watch: A feasibility study of intensive remote symptom monitoring via automated text messages with integrated nurse practitioner triage for patients with cancer and suspected or confirmed COVID-19.

Cody Cotner, Christopher Manz, Mohan Balachandran, Will Ferrell, Neda Khan, Michael Kopinsky, Suzanne McGettigan, Anna Morgan, Lindsey Zinck, Lynn Mara Schuchter, Lawrence N. Shulman, David Asch, Ravi B. Parikh.
Read the publication here

Disparities in end-of-life inpatient care received by patients with metastatic cancer, 2010 to 2017.

Stephanie Deeb, Fumiko Chino, Lisa Diamond, Anna Tao, Abraham Aragones, Armin Shahrokni, Divya Yerramilli, Erin F. Gillespie, C. Jillian Tsai.
Watch the Oral Abstract Session here.

Multi-site practice and physician travel burden by oncology specialty.

Zachary A. K. Frosch, Katherine Hicks-Courant, Justin E. Bekelman, Emily M. Ko, Genevieve P. Kanter.
Read the publication here

Willingness to travel for CAR-T: A choice-based conjoint analysis.

Zachary A. K. Frosch, Esin C. Namoglu, Nandita Mitra, Daniel Jeffrey Landsburg, Sunita Nasta, Judy Shea, Justin E. Bekelman, Carmen E. Guerra, Marilyn M. Schapira.
Read the publication here.

Phase 2 trial of gemcitabine, cisplatin, plus nivolumab with selective bladder sparing in patients with muscle- invasive bladder cancer (MIBC): HCRN GU 16-257.

Matt D. Galsky, Siamak Daneshmand, Kevin G. Chan, Tanya B. Dorff, Jeremy Paul Cetnar, Brock O Neil, Anishka D’souza, Ronac Mamtani, Christos Kyriakopoulos, Philip Garcia, Sudeh Izadmehr, Menggang Yu, Qianqian Zhao, Reza Mehrazin, Sara C Lewis, John Sfakianos, Sumanta K. Pal.
Watch the Oral Abstract Session here, broadcasting June 7th at 8am EDT.

Accrual of Black participants to cancer clinical trials following a five-year prospective initiative of community outreach and engagement.

Carmen E. Guerra, Vicki Sallee, Wei-Ting Hwang, Brenda Bryant, Armenta L. Washington, Samuel U. Takvorian, Robert Schnoll, Karen Glanz, Roger B. Cohen, Katherine L. Nathanson, Robert H. Vonderheide.
Watch the Clinical Science Symposium here, broadcasting June 5th at 10:30am EDT.

Intensity of end-of-life care for gynecologic cancer patients by primary oncologist specialty.

Katherine Hicks-Courant, Genevieve P. Kanter, Marilyn M. Schapira, Colleen Brensinger, Qing Liu, Emily M. Ko.
Watch the Poster Session here

Community-based lung cancer screening adherence to Lung-RADS recommendations.

Roger Kim, Katharine A. Rendle, Christine Neslund-Dudas, Robert T. Greenlee, Andrea N. Burnett-Hartman, Stacey A. Honda, Michael J. Simoff, Jennifer M. Croswell, Debra P. Ritzwoller, Anil Vachani.
Watch the Poster Session here.

Association between timely targeted therapy initiation and clinical outcomes in patients with advanced HER2+ gastroesophageal adenocarcinoma.

Kelsey S. Lau-Min, Yimei Li, Jennifer Rachel Eads, Ronac Mamtani, Kelly D. Getz.
Read the publication here

Oncologist phenotypes and associations with response to a behavioral intervention to increase serious illness conversations.

Eric Li, Christopher Manz, Manqing Liu, Jinbo Chen, Corey Chivers, Jennifer Braun, Lynn Mara Schuchter, Pallavi Kumar, Mitesh S. Patel, Lawrence N. Shulman, Ravi B. Parikh.
Watch the Poster Session here

Trajectories of machine learning-predicted mortality risk among patients with cancer and associated end-of-life utilization.

Manqing Liu, Jinbo Chen, Eric Li, Runze Li, Ravi B. Parikh.
Watch the Poster Session here.

Quality of life, functioning, and symptoms in patients with previously treated locally advanced or metastatic urothelial carcinoma from EV-301: A randomized phase 3 trial of enfortumab vedotin versus chemotherapy.

Ronac Mamtani, Jonathan E. Rosenberg, Thomas Powles, Guru P. Sonpavde, Yohann Loriot, Ignacio Duran, Jae-Lyun Lee, Nobuaki Matsubara, Christof Vulsteke, Daniel Castellano, Srikala S. Sridhar, Helle Pappot, Begoña P. Valderrama, Howard Gurney, Jens Bedke, Michiel Simon Van Der Heijden, Chunzhang Wu, Zsolt Hepp, Caroline McKay, Daniel P. Petrylak.
Watch the Poster Session here.

Multidisciplinary consensus recommendations for the management of non-spine bone metastases: Results of a modified Delphi process in a community-academic partnership.

Noah J Mathis, Jonathan T. Yang, Maksim Vaynrub, Ernesto Santos Martin, Rupesh Kotecha, Joseph Panoff, Andrew L. Salner, Alyson F McIntosh, Ranju Gupta, Amitabh Gulati, Divya Yerramilli, Amy Xu, Meredith Bartelstein, David Guttmann, Yoshiya Yamada, David G. Pfister, Diana Lin, Kaitlyn Lapen, Allison Lipitz-Snyderman, Erin F. Gillespie.
Read the publication here

Completion of lung cancer screening after a baseline order for LDCT at five diverse health systems.

Christine Neslund-Dudas, Amy Tang, Elizabeth Alleman, Jennifer Elston Lafata, Stacey A. Honda, Caryn Oshiro, Katharine A. Rendle, Anil Vachani, Oluwatosin Olaiya, Robert T. Greenlee, Michael J. Simoff, Debra P. Ritzwoller.
Watch the Oral Abstract Session here

Augmenting machine learning algorithms to predict mortality using patient-reported outcomes in oncology.

Ravi B. Parikh, Jill Schnall, Manqing Liu, Peter E. Gabriel, Corey Chivers, Michael Draugelis, Will Ferrell, Caryn Lerman, Justin E. Bekelman, Jinbo Chen.
Watch the Poster Discussion Session here.

Uptake and effectiveness of checkpoint inhibitor therapy among trial-ineligible patients with advanced solid malignancies.

Ravi B. Parikh, Eun Jeong Min, E. Paul Wileyto, Fauzia Riaz, Cary Philip Gross, Roger B. Cohen, Rebecca A. Hubbard, Qi Long, Ronac Mamtani.
Read the publication here

The association of the affordable care’s Medicaid expansion on survival in gynecologic cancer: A National Cancer Database study.

Anna Jo Smith, Jeremy Applebaum, Amanda Nickles Fader.
Watch the Oral Abstract Session here.

Impact of COVID-19 pandemic on time to treatment initiation for patients with advanced cancer.

Samuel U. Takvorian, Ravi B. Parikh, Daniel Vader, E. Paul Wileyto, Amy Sanders Clark, Daniel J. Lee, Gaurav Goyal, Gabrielle Betty Rocque, Efrat Dotan, Daniel M. Geynisman, Pooja Phull, Philippe E. Spiess, Roger Kim, Amy J. Davidoff, Cary Philip Gross, Rebecca A. Miksad, Gregory Sampang Calip, Lawrence N. Shulman, Ronac Mamtani, Rebecca A. Hubbard.
Watch the Poster Session here

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